Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator
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Correction: Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator
Regulatory networks allow organisms to match adaptive behavior to the complex and dynamic contingencies of their native habitats. Upon a sudden transition to a novel environment, the mismatch between the native behavior and the new niche provides selective pressure for adaptive evolution through mutations in elements that control gene expression. In the case of core components of cellular regul...
متن کاملSupporting Text for Fitness landscape transformation through a single amino acid change in the Rho terminator
1 Supplementary Methods 2 1.1 Bacterial strains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Condition screening . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.3 Growth Curves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.4 Transcriptome quantitation . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.5 Mutagenize...
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Cellular interleukin 10s (cIL-10s) of human and murine origin have extensive sequence and structural homology to the Epstein-Barr virus BCRF-I gene product, known as viral IL-10 (vIL-10). Although these cytokines share many immunosuppressive properties, vIL-10 lacks several of the immunostimulatory activities of cIL-10 on certain cell types. The molecular and cellular bases for this dichotomy a...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2012
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002744